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Untangling the estrogen receptor web

GPR30, a G-protein coupled receptor, is a recent addition to the family of receptors that bind to estrogens and antiestrogens. A new, selective compound for GPR30 has been developed to dissect the role of GPR30 in estrogen signaling.

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Figure 1: Estrogen signaling pathways in a cell.

References

  1. Bologa, C.G. et al. Nature Chem. Biol. 2, 207–212 (2006).

    Article  CAS  Google Scholar 

  2. Jordan, V.C. J. Med. Chem. 46, 1081–1111 (2003).

    Article  CAS  Google Scholar 

  3. Koehler, K.F., Helguero, L.A., Haldosen, L.A., Warner, M. & Gustafsson, J.Å. Endocr. Rev. 26, 465–478 (2005).

    Article  CAS  Google Scholar 

  4. Chadwick, C.C. et al. Proc. Natl. Acad. Sci. USA 102, 2543–2548 (2005).

    Article  CAS  Google Scholar 

  5. Losel, R.M. et al. Physiol. Rev. 83, 965–1016 (2003).

    Article  Google Scholar 

  6. Filardo, E.J., Quinn, J.A., Bland, K.I. & Frackelton, A.R. Mol. Endocrinol. 14, 1649–1660 (2000).

    Article  CAS  Google Scholar 

  7. Revankar, C.M., Cimino, D.F., Sklar, L.A., Arterburn, JB. & Prossnitz, E.R. Science 307, 1625–1630 (2005).

    Article  CAS  Google Scholar 

  8. Pietras, R.J., Levin, E.R. & Szego, C.M. Science 310, 51–53 (2005).

    Article  CAS  Google Scholar 

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Weatherman, R. Untangling the estrogen receptor web. Nat Chem Biol 2, 175–176 (2006). https://doi.org/10.1038/nchembio0406-175

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