Protein α-helices often terminate in recognizable helix-capping motifs. The origin of thermodynamic stability for one such motif is now well understood.
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References
Pauling, L., Corey, R.B. & Branson, H.R. Proc. Natl. Acad. Sci. USA 37, 205–210 (1951).
Aurora, R. & Rose, G.D. Protein Sci. 7, 21–38 (1998).
Bang, D. et al. Nat. Chem. Biol. 2, 139–143 (2006).
Aurora, R., Srinivasan, R. & Rose, G.D. Science 264, 1126–1130 (1994).
Ramachandran, G.N. & Sasisekharan, V. Adv. Prot. Chem. 23, 283–438 (1968).
Thomas, S.T., Loladze, V.V. & Makhatadze, G.I. Proc. Natl. Acad. Sci. USA 98, 10670–10675 (2001).
Ermolenko, D.N., Thomas, S.T., Aurora, R., Gronenborn, A.M. & Makhatadze, G.I. J. Mol. Biol. 322, 123–135 (2002).
Serrano, L., Sancho, J., Hirshberg, M. & Fersht, A.R. J. Mol. Biol. 227, 544–559 (1992).
Schneider, J.P. & DeGrado, W.F. J. Am. Chem. Soc. 120, 2764–2767 (1998).
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Rose, G. Lifting the lid on helix-capping. Nat Chem Biol 2, 123–124 (2006). https://doi.org/10.1038/nchembio0306-123
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DOI: https://doi.org/10.1038/nchembio0306-123