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Killing 84 birds with one stone

Nature Chemical Biology volume 5, pages 7677 (2009) | Download Citation

Subjects

Syntheses of natural product–like compound libraries with high scaffold diversity have proven hard to develop. A strategy employing metathesis cascades to 'zip up' a set of unsaturated building blocks differently connected by variable linkers demonstrates that over 80 distinct scaffold classes can be synthesized in one go.

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Affiliations

  1. Herbert Waldmann is at the Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany, and Universität Dortmund, Fakultät für Chemie, Chemische Biologie. herbert.waldmann@mpi-dortmund.mpg.de

    • Herbert Waldmann

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DOI

https://doi.org/10.1038/nchembio0209-76

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