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Killing 84 birds with one stone

Nature Chemical Biology volume 5, pages 7677 (2009) | Download Citation


Syntheses of natural product–like compound libraries with high scaffold diversity have proven hard to develop. A strategy employing metathesis cascades to 'zip up' a set of unsaturated building blocks differently connected by variable linkers demonstrates that over 80 distinct scaffold classes can be synthesized in one go.

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  1. 1.

    & Angew. Chem. Int. Ed. 43, 46–58 (2004).

  2. 2.

    et al. Proc. Natl. Acad. Sci. USA 103, 10606–10611 (2006).

  3. 3.

    , , , & Angew. Chem. Int. Ed. 48, 104–109 (2009).

  4. 4.

    , & Angew. Chem. Int. Ed. 41, 2878–2890 (2002).

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  1. Herbert Waldmann is at the Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany, and Universität Dortmund, Fakultät für Chemie, Chemische Biologie.

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