A powerful technology called global protein stability profiling allows rates of protein turnover to be determined for a substantial fraction of the human proteome in a single experiment. This approach sets the stage for systems-level analyses of the dynamics of the mammalian proteome.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Yen, H.C., Xu, Q., Chou, D.M., Zhao, Z. & Elledge, S.J. Science 322, 918–923 (2008).
Yen, H.C. & Elledge, S.J. Science 322, 923–929 (2008).
Newman, J.R. et al. Nature 441, 840–846 (2006).
Pickart, C.M. & Cohen, R.E. Nat. Rev. Mol. Cell Biol. 5, 177–187 (2004).
Petroski, M.D. & Deshaies, R.J. Nat. Rev. Mol. Cell Biol. 6, 9–20 (2005).
Mann, M. Nat. Rev. Mol. Cell Biol. 7, 952–958 (2006).
Cox, J. & Mann, M. Cell 130, 395–398 (2007).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ang, X., Harper, J. A road map of cellular protein homeostasis. Nat Chem Biol 5, 9–11 (2009). https://doi.org/10.1038/nchembio0109-9
Issue Date:
DOI: https://doi.org/10.1038/nchembio0109-9