As cellular machines and processes that regulate the flow of genomic information have come into sharper focus, a new level of chemical control has become possible. The scope of such chemical intervention extends from the mechanistic dissection of biochemical processes in living cells to the targeted control of gene networks and cell fate.
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Acknowledgements
I apologize to many friends and colleagues whom I could not reference, and I thank those who generously helped in assembling this commentary. The support of the US National Institutes of Health and the Shaw and Keck foundations is gratefully acknowledged.
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Ansari, A. Chemical crosshairs on the central dogma. Nat Chem Biol 3, 2–7 (2007). https://doi.org/10.1038/nchembio0107-2
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DOI: https://doi.org/10.1038/nchembio0107-2