News & Views | Published:

Preventing protein secretion with chemical glue

Nature Chemical Biology volume 2, pages 78 (2006) | Download Citation

Subjects

A small-molecule inhibitor of protein secretion has been found that targets Cdc42, a regulator of the secretory pathway. This compound acts through a previously undescribed mechanism—by recruiting a protein inhibitor.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Nature 432, 846–854 (2004).

  2. 2.

    et al. Nat. Chem. Biol. 2, 39–46 (2006).

  3. 3.

    & Curr. Opin. Struct. Biol. 10, 401–404 (2000).

  4. 4.

    Sci. STKE 2004, RE13 (2004).

  5. 5.

    & Curr. Opin. Genet. Dev. 15, 62–68 (2005).

  6. 6.

    , , , & J. Am. Chem. Soc. 123, 6740–6741 (2001).

Download references

Author information

Affiliations

  1. Brent R. Stockwell is in the Department of Biological Sciences and the Department of Chemistry, Columbia University, Fairchild Center MC2406, 1212 Amsterdam Avenue, New York, New York 10027, USA. stockwell@biology.columbia.edu

    • Brent R Stockwell

Authors

  1. Search for Brent R Stockwell in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nchembio0106-7

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing