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Agonizing Hedgehog

Nature Chemical Biology volume 2, pages 1011 (2006) | Download Citation

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Hedgehog signaling has important and pleiotropic roles in embryonic and adult tissues. A small-molecule agonist of this pathway has been shown to act by targeting the transmembrane protein Smoothened.

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References

  1. 1.

    , & Nat. Rev. Cancer 2, 361–372 (2002).

  2. 2.

    & Nat. Chem. Biol. 2, 29–30 (2006).

  3. 3.

    , , , & J. Am. Chem. Soc. 124, 14520–14521 (2002).

  4. 4.

    , , , & Chem. Biol. 11, 1229–1238 (2004).

  5. 5.

    & Development 133, 3–14 (2006).

  6. 6.

    , , & Genes Dev. 16, 2743–2748 (2002).

  7. 7.

    , , , & Proc. Natl. Acad. Sci. USA 99, 14071–14076 (2002).

  8. 8.

    et al. J. Biol. 1, 10 (2002).

  9. 9.

    , , & Nature 418, 892–897 (2002).

  10. 10.

    et al. Nature 437, 1018–1021 (2005).

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Author information

Affiliations

  1. James Briscoe is in the Department of Developmental Neurobiology, National Institute for Medical Research, London, NW7 1AA, UK. james.briscoe@nimr.mrc.ac.uk

    • James Briscoe

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DOI

https://doi.org/10.1038/nchembio0106-10

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