Lysophosphatidic acid, a lipid mediator, second messenger and intermediate in lipid biosynthesis, finds a new intracellular target in TRPV1. This nonselective cation channel is also targeted by the analgesic capsaicin, which acts to desensitize the channel.
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References
Inoue, M. et al. Nat. Med. 10, 712–718 (2004).
Kakiuchi, Y. et al. Mol. Pain 7, 33 (2011).
Nieto-Posadas, A. et al. Nat. Chem. Biol. 8, 78–85 (2012).
Caterina, M.J. et al. Science 288, 306–313 (2000).
Jara-Oseguera, A., Simon, S.A. & Rosenbaum, T. Curr. Mol. Pharmacol. 1, 255–269 (2008).
Brauchi, S. et al. Proc. Natl. Acad. Sci. USA 104, 10246–10251 (2007).
Zhang, H. et al. Cancer Res. 69, 5441–5449 (2009).
Bolen, A.L. et al. J. Lipid Res. 52, 958–970 (2011).
Tigyi, G. Br. J. Pharmacol. 161, 241–270 (2010).
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Tigyi, G. LPA activates TRPV1—and it hurts. Nat Chem Biol 8, 22–23 (2012). https://doi.org/10.1038/nchembio.738
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DOI: https://doi.org/10.1038/nchembio.738
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