Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Plant biology

Blocking galactolipid biosynthesis

Nature Chemical Biology volume 7, pages 761–762 (2011)Cite this article

Subjects

The first selective inhibitor of monogalactosyldiacylglycerol (MGDG) synthase was identified from a chemical library screen. The competitive inhibitor effectively targets MGDG concentrations across plant tissues and was used to demonstrate a new role for galactolipids in pollen-tube development.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Identification of an inhibitor of MGDG synthases.

References

  1. Aronsson, H. et al. Plant Physiol. 148, 580–592 (2008)10.1104/pp.108.123372.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Tjellström, H., Andersson, M.X., Larsson, K.E. & Sandelius, A.S. Plant Cell Environ. 31, 1388–1398 (2008)10.1111/j.1365-3040.2008.01851.x.

    Article  CAS  PubMed  Google Scholar 

  3. Botté, C. et al. Nat. Chem. Biol. 7, 834–842 (2011).10.1038/nchembio.658

    Article  CAS  PubMed  Google Scholar 

  4. Awai, K. et al. Proc. Natl. Acad. Sci. USA 98, 10960–10965 (2001)10.1073/pnas.181331498.

    Article  CAS  PubMed  Google Scholar 

  5. Kobayashi, K., Kondo, M., Fukuda, H., Nishimura, M. & Ohta, H. Proc. Natl. Acad. Sci. USA 104, 17216–17221 (2007)10.1073/pnas.0704680104.

    Article  PubMed  Google Scholar 

  6. Kobayashi, K., Awai, K., Takamiya, K. & Ohta, H. Plant Physiol. 134, 640–648 (2004)10.1104/pp.103.032656.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biological Sciences, Kent D. Chapman is at the Center for Plant Lipid Research, University of North Texas, Denton, Texas, USA.,

    Kent D Chapman

Authors
  1. Kent D Chapman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kent D Chapman.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chapman, K. Blocking galactolipid biosynthesis. Nat Chem Biol 7, 761–762 (2011). https://doi.org/10.1038/nchembio.691

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.691

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research