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Principles for designing fluorescent sensors and reporters

Nature Chemical Biology volume 7, pages 480–483 (2011)Cite this article

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Sensors and reporters are among the most exciting tools used in cell biology. Now, they are increasingly used in developmental biology and medicine because they allow us to spy on events in living cells and organisms, including humans, in real time and with high spatial resolution. Herein, we discuss multiple design options for fluorescent sensors and reporters as well as strategies to improve their properties and increase development.

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Figure 1: Example reporters and sensors with typical time resolution and application range.

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Authors and Affiliations

  1. Edward A. Lemke is in the Structural & Computational Biology Unit at the European Molecular Biology Laboratory, Heidelberg, Germany.,

    Edward A Lemke

  2. Carsten Schultz is in the Cell Biology & Biophysics Unit at the European Molecular Biology Laboratory, Heidelberg, Germany.,

    Carsten Schultz

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  1. Edward A Lemke
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  2. Carsten Schultz
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Correspondence to Edward A Lemke or Carsten Schultz.

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The authors declare no competing financial interests.

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Lemke, E., Schultz, C. Principles for designing fluorescent sensors and reporters. Nat Chem Biol 7, 480–483 (2011). https://doi.org/10.1038/nchembio.620

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