A small subpeptide from the tumor suppressor p53 is shown to mediate aggregation that is similar to that of amyloids. The result is nucleated assembly by mutant p53 that can abrogate function of wild-type p53 and its two functionally important homologs.
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References
Oren, M. & Rotter, V. Cold Spring Harb. Perspect. Biol. 2, a001107 (2010).
Joerger, A.C. & Fersht, A.R. Cold Spring Harb. Perspect. Biol. 2, a000919 (2010).
Xu, J. et al. Nat. Chem. Biol. 7, 285–295 (2011).
Fernandez-Escamilla, A.M., Rousseau, F., Schymkowitz, J. & Serrano, L. Nat. Biotechnol. 22, 1302–1306 (2004).
Li, Y. & Prives, C. Oncogene 26, 2220–2225 (2007).
Goldschmidt, L., Teng, P.K., Riek, R. & Eisenberg, D. Proc. Natl. Acad. Sci. USA 107, 3487–3492 (2010).
Ruschak, A.M. & Miranker, A.D. Proc. Natl. Acad. Sci. USA 104, 12341–12346 (2007).
Hebda, J.A. & Miranker, A.D. Annu. Rev. Biophys. 38, 125–152 (2009).
Hebda, J.A., Saraogi, I., Magzoub, M., Hamilton, A.D. & Miranker, A.D. Chem. Biol. 16, 943–950 (2009).
Sawaya, M.R. et al. Nature 447, 453–457 (2007).
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Magzoub, M., Miranker, A. p53 succumbs to peer pressure. Nat Chem Biol 7, 248–249 (2011). https://doi.org/10.1038/nchembio.569
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DOI: https://doi.org/10.1038/nchembio.569