Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Grand Challenge Commentary: RNA epigenetics?

Post-transcriptional RNA modifications can be dynamic and might have functions beyond fine-tuning the structure and function of RNA. Understanding these RNA modification pathways and their functions may allow researchers to identify new layers of gene regulation at the RNA level.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Examples of RNA modification and demodification that may impact biological regulation.


  1. Grosjean, H. (Ed.) Topics in Current Genetics Vol. 12 (Springer, Berlin, 2005).

    Google Scholar 

  2. Anderson, J. et al. Genes Dev. 12, 3650–3662 (1998).

    Article  CAS  Google Scholar 

  3. Saikia, M. et al. RNA 16, 1317–1327 (2010).

    Article  CAS  Google Scholar 

  4. Goll, M.G. et al. Science 311, 395–398 (2006).

    Article  CAS  Google Scholar 

  5. Schaefer, M. & Lyko, F. Chromosoma 119, 35–40 (2010).

    Article  CAS  Google Scholar 

  6. Yan, F. et al. J. Am. Chem. Soc. 132, 3953–3964 (2010).

    Article  CAS  Google Scholar 

  7. Toh, S.M. et al. Mol. Microbiol. 64, 1506–1514 (2007).

    Article  CAS  Google Scholar 

  8. Yi, C., Yang, C.G. & He, C. Acc. Chem. Res. 42, 519–529 (2009).

    Article  CAS  Google Scholar 

  9. Trewick, S.C. et al. Nature 419, 174–178 (2002).

    Article  CAS  Google Scholar 

  10. Falnes, P.Ø., Johansen, R.F. & Seeberg, E. Nature 419, 178–182 (2002).

    Article  CAS  Google Scholar 

  11. Fu, Y. et al. Angew. Chem. Int. Ed. published online, doi:10.1002/anie.201001242 (25 June 2010).

  12. Shimada, K. et al. Cancer Res. 69, 3157–3164 (2009).

    Article  CAS  Google Scholar 

  13. Aas, P.A. et al. Nature 421, 859–863 (2003).

    Article  CAS  Google Scholar 

  14. Shimada, K. et al. Cancer Sci. 99, 39–45 (2008).

    CAS  PubMed  Google Scholar 

  15. Frayling, T.M. et al. Science 316, 889–894 (2007).

    Article  CAS  Google Scholar 

  16. Dina, C. et al. Nat. Genet. 39, 724–726 (2007).

    Article  CAS  Google Scholar 

  17. Scott, L.J. et al. Science 316, 1341–1345 (2007).

    Article  CAS  Google Scholar 

  18. Gerken, T. et al. Science 318, 1469–1472 (2007).

    Article  CAS  Google Scholar 

  19. Webby, C.J. et al. Science 325, 90–93 (2009).

    Article  CAS  Google Scholar 

  20. Hong, X. et al. Proc. Natl. Acad. Sci. USA 107, 14568–14572 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Chuan He.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

He, C. Grand Challenge Commentary: RNA epigenetics?. Nat Chem Biol 6, 863–865 (2010).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing