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Protein engineering

Check nature first, then evolve

Nature Chemical Biology volume 6, pages 793–794 (2010)Cite this article

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Ten significantly active new (R)-transaminases, still very rare enzymes, were found among 21 designed variants obtained from nothing more than existing transaminase structures and alignment of pertinent fingerprints of annotated sequences.

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Figure 1: Evaluation of active site environment and of fingerprints in multiple sequence alignments of transaminases.

Katherine Vicari

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Authors and Affiliations

  1. Andreas S. Bommarius is in the School of Chemical and Biomolecular Engineering and the School of Chemistry and Biochemistry, Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta.,

    Andreas S Bommarius

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  1. Andreas S Bommarius
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Correspondence to Andreas S Bommarius.

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Bommarius, A. Check nature first, then evolve. Nat Chem Biol 6, 793–794 (2010). https://doi.org/10.1038/nchembio.461

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