The RNA-activated protein kinase PKR inhibits translation initiation by sensing long viral double-stranded RNA. A new report indicates that PKR is also activated by a cellular mRNA, but only when ribosomes are not initiating translation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Lee, F. & Yanofsky, C. Proc. Natl. Acad. Sci. USA 74, 4365–4369 (1977).
Babitzke, P. & Yanofsky, C. Proc. Natl. Acad. Sci. USA 90, 133–137 (1993).
Winkler, W.C. & Breaker, R.R. ChemBioChem 4, 1024–1032 (2003).
Henkin, T.M. Genes Dev. 22, 3383–3390 (2008).
Nudler, E. & Mironov, A.S. Trends Biochem. Sci. 29, 11–17 (2004).
Cohen-Chalamish, S. et al. Nat. Chem. Biol. 5, 896–903 (2009).
Balachandran, S. et al. Immunity 13, 129–141 (2000).
Garcia, M.A. et al. Microbiol. Mol. Biol. Rev. 70, 1032–1060 (2006).
Yueh, A. & Schneider, R.J. Genes Dev. 10, 1557–1567 (1996).
Holbrook, S.R. Curr. Opin. Struct. Biol. 15, 302–308 (2005).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Toroney, R., Bevilacqua, P. PKR and the ribosome compete for mRNA. Nat Chem Biol 5, 873–874 (2009). https://doi.org/10.1038/nchembio.262
Issue Date:
DOI: https://doi.org/10.1038/nchembio.262