Two iron regulatory proteins (IRP1 and IRP2) regulate translation and/or stability of mRNAs encoding proteins required for iron storage, acquisition and utilization. Rather than IRP2 directly sensing iron concentrations, iron has been shown to regulate the level of the SKP1-CUL1-FBXL5 E3 ubiquitin ligase protein complex, which is responsible for IRP2 degradation.
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Takahashi-Makise, N., Ward, D. & Kaplan, J. On the mechanism of iron sensing by IRP2: new players, new paradigms. Nat Chem Biol 5, 874–875 (2009). https://doi.org/10.1038/nchembio.261
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DOI: https://doi.org/10.1038/nchembio.261
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