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Redox regulation

Scaffolding H2O2 signaling

Peroxidases, rather than simply reducing H2O2 to water, also convey oxidation signals to proteins such as transcription factors. A new study reveals how a scaffold protein enables formation of a mixed disulfide between the peroxidase and a transcription factor.

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Figure 1: A ternary complex ensures H2O2-mediated oxidation of Yap1.

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Correspondence to Hadley D Sikes.

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Sikes, H. Scaffolding H2O2 signaling. Nat Chem Biol 13, 818–819 (2017). https://doi.org/10.1038/nchembio.2432

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