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Peptidoglycan

Another brick in the wall

Nature Chemical Biology volume 13, pages 695–696 (2017)Cite this article

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Lipid II embodies the bricks used to build the essential bacterial cell wall component peptidoglycan. A facile new procedure for preparation of species-specific Lipid II in high yields can now be used to unlock the door to antibiotic discovery.

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Figure 1: Production of Lipid II and its use to assay penicillin-binding proteins (PBPs).

References

  1. Park, J.T. & Strominger, J.L. Science 125, 99–101 (1957).

    Article  CAS  Google Scholar 

  2. Qiao, Y. et al. Nat. Chem. Biol. 13, 793–798 (2017).

    Article  CAS  Google Scholar 

  3. Schleifer, K.H. & Kandler, O. Bacteriol. Rev. 36, 407–477 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Vollmer, W., Blanot, D. & de Pedro, M.A. FEMS Microbiol. Rev. 32, 149–167 (2008).

    Article  CAS  Google Scholar 

  5. Turner, R.D., Vollmer, W. & Foster, S.J. Mol. Microbiol. 91, 862–874 (2014).

    Article  CAS  Google Scholar 

  6. Lloyd, A.J. et al. J. Biol. Chem. 283, 6402–6417 (2008).

    Article  CAS  Google Scholar 

  7. Goffin, C. & Ghuysen, J.M. Microbiol. Mol. Biol. Rev. 62, 1079–1093 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Meeske, A.J. et al. Nature 537, 634–638 (2016).

    Article  CAS  Google Scholar 

  9. Braddick, D., Sandhu, S., Roper, D.I., Chappell, M.J. & Bugg, T.D. Microbiology 160, 1628–1636 (2014).

    Article  CAS  Google Scholar 

  10. Moynihan, P.J., Sychantha, D. & Clarke, A.J. Bioorg. Chem. 54, 44–50 (2014).

    Article  CAS  Google Scholar 

Download references

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  1. Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada

    Anthony J Clarke

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  1. Anthony J Clarke
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Correspondence to Anthony J Clarke.

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The author declares no competing financial interests.

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Clarke, A. Another brick in the wall. Nat Chem Biol 13, 695–696 (2017). https://doi.org/10.1038/nchembio.2419

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