Compound 1

1-(1-benzylpiperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)urea

From: Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase

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Synonyms:
  • NAcM-OPT

Synthetic procedure: See article for the definitive version of this procedure and for full experimental details.

m.p.: 178-180 °C. 1H NMR (400 MHz, DMSO-d6) δ 8.71 (s, 1H), 7.96 (s, 1H), 7.48 – 7.40 (m, 2H), 7.35 – 7.27 (m, 4H), 7.27 – 7.19 (m, 2H), 6.24 (d, J = 7.6 Hz, 1H), 3.56 – 3.40 (m, 3H), 2.75 – 2.65 (m, 2H), 2.07 (t, J = 11.0 Hz, 2H), 1.84 – 1.75 (m, 2H), 1.47 – 1.33 (m, 2H). 13C NMR (101 MHz, DMSO-d6) δ 154.3, 141.3, 138.5, 129.7, 129.4 (q, J = 31.3 Hz), 128.8, 128.2, 126.9, 124.3 (q, J = 272.3 Hz), 121.0, 117.2 (q, J = 4.0 Hz), 113.4 (q, J = 4.0 Hz), 62.2, 51.7, 46.3, 32.0. HRMS (ESI+) m/z calcd for C20H23F3N3O [M+H]+ 378.1793, found 378.1790.

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