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RAS signaling

Divide and conquer

Nature Chemical Biology volume 13, pages 7–8 (2017)Cite this article

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The role of RAS dimerization in tumor biology is an emerging area of preclinical cancer research. Characterization of a RAS monobody indicates that dimer formation is required for RAS signaling, revealing the dimer interface as a potential drug target.

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Figure 1: Disrupting RAS dimers inhibits RAF dimerization and activation.

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Authors and Affiliations

  1. Matthew Holderfield is at the NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, National Cancer Institute, Frederick, Maryland, USA.,

    Matthew Holderfield

  2. Deborah K. Morrison is at the Laboratory of Cell and Developmental Signaling, National Cancer Institute, Frederick, Maryland, USA.,

    Deborah K Morrison

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  1. Matthew Holderfield
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  2. Deborah K Morrison
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Correspondence to Deborah K Morrison.

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The authors declare no competing financial interests.

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Holderfield, M., Morrison, D. Divide and conquer. Nat Chem Biol 13, 7–8 (2017). https://doi.org/10.1038/nchembio.2264

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