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Ferroptosis

Oxidized PEs trigger death

Ferroptosis is characterized by accumulation of lipid peroxidation products and lethal ROS, but the source and identity of lipid death signals that cause toxicity are poorly defined. New studies reveal that ACSL4 controls sensitivity to ferroptosis and that oxidized phosphatidylethanolamines are critical for ferroptosis execution.

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Figure 1: Mechanism of ferroptosis execution and generation of oxidized phosphatidylethanolamines.

Kim Caesar/Springer Nature

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Correspondence to Dmitri V Krysko.

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D'Herde, K., Krysko, D. Oxidized PEs trigger death. Nat Chem Biol 13, 4–5 (2017). https://doi.org/10.1038/nchembio.2261

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