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Ferroptosis

Oxidized PEs trigger death

Nature Chemical Biology volume 13, pages 45 (2017) | Download Citation

Ferroptosis is characterized by accumulation of lipid peroxidation products and lethal ROS, but the source and identity of lipid death signals that cause toxicity are poorly defined. New studies reveal that ACSL4 controls sensitivity to ferroptosis and that oxidized phosphatidylethanolamines are critical for ferroptosis execution.

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Author information

Affiliations

  1. Katharina D'Herde is at the Department of Basic Medical Sciences, and Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.

    • Katharina D'Herde
  2. Dmitri V. Krysko is at the Department of Basic Medical Sciences and Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.

    • Dmitri V Krysko

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Dmitri V Krysko.

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DOI

https://doi.org/10.1038/nchembio.2261

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