Parathyroid hormone (PTH) and PTH-related protein activate the same receptor but can produce divergent effects. Reports now describe two active conformations for the PTH receptor, one of which moves intracellularly—complexed with hormone and G protein—to produce a continued cAMP signal.
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Rosenblatt, M. When two keys fit one lock, surprises follow. Nat Chem Biol 5, 707–708 (2009). https://doi.org/10.1038/nchembio.225
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DOI: https://doi.org/10.1038/nchembio.225
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