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Genetic engineering

Chemical control for CRISPR editing

New approaches allow tight control over Cas9 activity using chemical induction. These studies expand the ability to rapidly induce and suppress Cas9-mediated nuclease activity and conditionally modulate the multiplex regulation of endogenous gene expression.

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Figure 1: New strategies for combining novel fusion proteins and small molecules to control the activity of Cas9 in human cells.

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Correspondence to Charles A Gersbach.

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Hilton, I., Gersbach, C. Chemical control for CRISPR editing. Nat Chem Biol 13, 2–3 (2017). https://doi.org/10.1038/nchembio.2243

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