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A new layer of glycolysis

Glucose metabolism has long been thought to operate with exquisite specificity and near-optimal efficiency. New findings show, however, that two glycolytic enzymes produce minor products that inhibit other enzymes involved in central carbon metabolism unless they are further metabolized by a novel enzyme.

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Figure 1: Glycolysis, side-product formation, and repair by PGP/PHO13.


  1. Liberti, M.V. & Locasale, J.W. Trends Biochem. Sci. 41, 211–218 (2016).

    Article  CAS  Google Scholar 

  2. Bar-Even, A., Flamholz, A., Noor, E. & Milo, R. Nat. Chem. Biol. 8, 509–517 (2012).

    Article  CAS  Google Scholar 

  3. Rabinowitz, J.D. & Vastag, L. Nat. Chem. Biol. 8, 497–501 (2012).

    Article  CAS  Google Scholar 

  4. Collard, F. et al. Nat. Chem. Biol. 12, 601–607 (2016).

    Article  CAS  Google Scholar 

  5. Madhukar, N.S., Warmoes, M.O. & Locasale, J.W. PLoS One 10, e0117131 (2015).

    Google Scholar 

  6. Shestov, A.A. et al. eLife 3, e03342 (2014).

    Article  Google Scholar 

  7. Intlekofer, A.M. et al. Cell Metab. 22, 304–311 (2015).

    Article  CAS  Google Scholar 

  8. Fan, J. et al. ACS Chem. Biol. 10, 510–516 (2015).

    Article  CAS  Google Scholar 

  9. Okar, D.A. et al. Trends Biochem. Sci. 26, 30–35 (2001).

    Article  CAS  Google Scholar 

  10. Kim, S.R. et al. Appl. Environ. Microbiol. 81, 1601–1609 (2015).

    Article  Google Scholar 

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Correspondence to Jason W Locasale.

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Liberti, M., Locasale, J. A new layer of glycolysis. Nat Chem Biol 12, 577–578 (2016).

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