Phosphoglycerate dehydrogenase (PHGDH) is an enzyme of serine biosynthesis overexpressed in various types of cancer. A new series of PHGDH inhibitors selectively block proliferation of PHGDH-dependent cancer cells and reveal an unexpected role of serine biosynthesis in coordinating one-carbon metabolism.
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Frezza, C. Addicted to serine. Nat Chem Biol 12, 389–390 (2016). https://doi.org/10.1038/nchembio.2086
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DOI: https://doi.org/10.1038/nchembio.2086
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