Cdk1 links mitotic entry to faithful chromosome segregation by activating the acetyltransferase TIP60. Acetylation of Aurora B kinase by TIP60 protects Aurora B's activation loop from dephosphorylation by the PP2A phosphatase to ensure robust Aurora B activation.
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Zachos, G. TIPs for shaping Aurora B activity. Nat Chem Biol 12, 204–205 (2016). https://doi.org/10.1038/nchembio.2041
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DOI: https://doi.org/10.1038/nchembio.2041
