A new high-resolution crystal structure of the subdomain from a catalytically active group II intron reveals important conformational rearrangements necessary to achieve the fully formed catalyst. This structure provides the first atomic-resolution structure of an RNA folding intermediate.
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Solem, A., Laederach, A. A clear path to RNA catalysis. Nat Chem Biol 11, 906–908 (2015). https://doi.org/10.1038/nchembio.1954
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DOI: https://doi.org/10.1038/nchembio.1954
