The long-awaited crystal structure of the Varkud satellite (VS) ribozyme dimer provides atomic-level insights into how the VS ribozyme folds and catalyzes RNA circularization during rolling circle replication, as well as revealing convergent evolution used by RNAs to catalyze an SN2 reaction.
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Zhong, Z., Chen, G. How RNA catalyzes cyclization. Nat Chem Biol 11, 830–831 (2015). https://doi.org/10.1038/nchembio.1928
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DOI: https://doi.org/10.1038/nchembio.1928
