The recent emergence of signaling roles for transition metals presages a broader contribution of these elements beyond their traditional functions as metabolic cofactors. New chemical approaches to identify the sources, targets and physiologies of transition-metal signaling can help expand understanding of the periodic table in a biological context.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells
Nature Communications Open Access 04 January 2021
-
Recent Endeavors on Molecular Imaging for Mapping Metals in Biology
Biophysics Reports Open Access 04 October 2020
-
φXANES: In vivo imaging of metal-protein coordination environments
Scientific Reports Open Access 10 February 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Lippard, S.J. & Berg, J.M. Principles of Bioinorganic Chemistry (University Science Books, Mill Valley, California, USA, 1994).
Alberts, B. et al. Molecular Biology of the Cell 5th edn. (Garland Science, Taylor & Francis Group, New York, 2008).
Maske, H. Naturwissenschaften 42, 424 (1955).
Kim, A.M., Vogt, S., O'Halloran, T.V. & Woodruff, T.K. Nat. Chem. Biol. 6, 674–681 (2010).
Kim, A.M. et al. ACS Chem. Biol. 6, 716–723 (2011).
Que, E.L. et al. Nat. Chem. 7, 130–139 (2014).
Vander Heiden, M.G., Cantley, L.C. & Thompson, C.B. Science 324, 1029–1033 (2009).
Turski, M.L. et al. Mol. Cell. Biol. 32, 1284–1295 (2012).
Brady, D.C. et al. Nature 509, 492–496 (2014).
Dixon, S.J. et al. Cell 149, 1060–1072 (2012).
Dixon, S.J. & Stockwell, B.R. Nat. Chem. Biol. 10, 9–17 (2014).
Yang, W.S. et al. Cell 156, 317–331 (2014).
Que, E.L., Domaille, D.W. & Chang, C.J. Chem. Rev. 108, 1517–1549 (2008).
Bush, A.I. Curr. Opin. Chem. Biol. 4, 184–191 (2000).
Burdette, S.C. & Lippard, S.J. Proc. Natl. Acad. Sci. USA 100, 3605–3610 (2003).
Carter, K.P., Young, A.M. & Palmer, A.E. Chem. Rev. 114, 4564–4601 (2014).
Kawabata, E. et al. J. Am. Chem. Soc. 127, 818–819 (2005).
Pan, E. et al. Neuron 71, 1116–1126 (2011).
Anderson, C.T. et al. Proc. Natl. Acad. Sci. USA 112, E2705–E2714 (2015).
Dodani, S.C. et al. Proc. Natl. Acad. Sci. USA 108, 5980–5985 (2011).
Dodani, S.C. et al. Proc. Natl. Acad. Sci. USA 111, 16280–16285 (2014).
Chan, J., Dodani, S.C. & Chang, C.J. Nat. Chem. 4, 973–984 (2012).
Aron, A.T., Ramos-Torres, K.M., Cotruvo, J.A. Jr. & Chang, C.J. Acc. Chem. Res. 18, 2434–2442 (2015).
Franz, K.J. Curr. Opin. Chem. Biol. 17, 143–149 (2013).
Hong-Hermesdorf, A. et al. Nat. Chem. Biol. 10, 1034–1042 (2014).
Acknowledgements
I thank the Howard Hughes Medical Institute as well as the US National Institutes of Health (grant GM 79465) for generous research support of my interests in the study of metals at the chemistry-biology interface. I thank A. Aron for helpful feedback on an earlier draft of this article.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Chang, C. Searching for harmony in transition-metal signaling. Nat Chem Biol 11, 744–747 (2015). https://doi.org/10.1038/nchembio.1913
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.1913
This article is cited by
-
Capturing copper to inhibit inflammation
Nature Chemical Biology (2023)
-
Disruption of zinc (II) binding and dimeric protein structure of the XIAP-RING domain by copper (I) ions
JBIC Journal of Biological Inorganic Chemistry (2023)
-
Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells
Nature Communications (2021)
-
Recent Endeavors on Molecular Imaging for Mapping Metals in Biology
Biophysics Reports (2020)
-
φXANES: In vivo imaging of metal-protein coordination environments
Scientific Reports (2016)