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A phenol sandwich fights diabetes

Nature Chemical Biology volume 11, pages 635636 (2015) | Download Citation

The complex flavonoid montbretin A (MbA) is a powerful inhibitor of human pancreatic amylase (HPA) and a potential tool in the treatment of type 2 diabetes. The X-ray structure of the MbA–HPA complex now shows that a hydrophobic collapse of two phenol fragments in the structure of MbA is key to its activity.

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Author information

Affiliations

  1. Anna Bernardi and Sara Sattin are in the Department of Chemistry, Universita' degli Studi di Milano, Milano, Italy.

    • Anna Bernardi
    •  & Sara Sattin

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Anna Bernardi.

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DOI

https://doi.org/10.1038/nchembio.1888

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