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Quo vadis, enzymology?

Enzymology has been a vital link between chemistry and biology in the second half of the twentieth century. A range of emerging scientific challenges is presenting the field with exciting opportunities to continue thriving in the future.

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Figure 1: Energy coupling in catalytic biological machines.
Figure 2: Enzyme transformations and protein modifications.
Figure 3: Brownian dynamics simulation of the cytoplasmic environment.

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Acknowledgements

I am grateful to C. Walsh for numerous discussions on the subject and for his feedback on an early draft of this article. Research on enzymology in my laboratory has been generously supported by the US National Institutes of Health (R01 GM087934 and R01 DK063158).

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Correspondence to Chaitan Khosla.

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Khosla, C. Quo vadis, enzymology?. Nat Chem Biol 11, 438–441 (2015). https://doi.org/10.1038/nchembio.1844

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