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Antifungal design

The toxicity-resistance yin-yang

Nature Chemical Biology volume 11, pages 453–454 (2015)Cite this article

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A modified amphotericin antifungal that is less toxic to human cells, owing to its increased preference for its fungal ergosterol target versus human cholesterol, can still evade the evolution of resistance.

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Figure 1: The chemical structures of AmB and the urea derivatives.

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Authors and Affiliations

  1. David M. Geiser is in the Department of Plant Pathology and Environmental Microbiology at Pennsylvania State University, University Park, Pennsylvania, USA.,

    David M Geiser

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  1. David M Geiser
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Correspondence to David M Geiser.

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The author declares no competing financial interests.

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Geiser, D. The toxicity-resistance yin-yang. Nat Chem Biol 11, 453–454 (2015). https://doi.org/10.1038/nchembio.1838

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