The pharmaceutical industry continues to experience significant attrition of drug candidates during phase 2 proof-of-concept clinical studies. We describe some questions about the characteristics of protein targets and small-molecule drugs that may be important to consider in drug-discovery projects and could improve prospects for future clinical success.
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Acknowledgements
We thank many colleagues at Pfizer for their input on this topic, including T. Rolph and members of the 'chemical biology network group'. We also thank S. Hualin Xi for the graph shown in Figure 1, R. Stanton for his help in establishing the Wikipedia entry, and P. Workman (Institute of Cancer Research, UK) and A. Edwards (University of Toronto) for their helpful feedback.
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Bunnage, M., Gilbert, A., Jones, L. et al. Know your target, know your molecule. Nat Chem Biol 11, 368–372 (2015). https://doi.org/10.1038/nchembio.1813
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DOI: https://doi.org/10.1038/nchembio.1813
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