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Metabolism

'Channeling' Hans Krebs

Nature Chemical Biology volume 11, pages 180–181 (2015)Cite this article

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The physical arrangement of enzymes within native metabolic pathways is emerging as an important but underexplored area of molecular biology. Recent advances in mass spectrometry enabled confirmation of the proposal that the Krebs cycle enzymes form a complex and suggest that substrate channeling is the most likely benefit to this structural arrangement.

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Figure 1: Crosslinking and mass spectrometry provide clues to substrate channeling among three Krebs cycle enzymes.

References

  1. Wu, F. & Minteer, S. Angew. Chem. Int. Edn. Engl. 10.1002/anie.201409336 (23 December 2014).

  2. Hyde, C.C., Ahmed, S.A., Padlan, E.A., Miles, E.W. & Davies, D.R. J. Biol. Chem. 263, 17857–17871 (1988).

    CAS  Google Scholar 

  3. Cameron, J.C., Wilson, S.C., Bernstein, S.L. & Kerfeld, C.A. Cell 155, 1131–1140 (2013).

    Article  CAS  Google Scholar 

  4. Montero Llopis, P. et al. Nature 466, 77–81 (2010).

    Article  Google Scholar 

  5. Savage, D.F., Afonso, B., Chen, A.H. & Silver, P.A. Science 327, 1258–1261 (2010).

    Article  CAS  Google Scholar 

  6. Khosla, C., Herschlag, D., Cane, D.E. & Walsh, C.T. Biochemistry 53, 2875–2883 (2014).

    Article  CAS  Google Scholar 

  7. Hu, Y. & Ribbe, M.W. Biochim. Biophys. Acta 1827, 1112–1122 (2013).

    Article  CAS  Google Scholar 

  8. Ovádi, J. & Srere, P.A. in Microcompartmentation and Phase Separation in Cytoplasm: A Survey of Cell Biology (International Review of Cytology vol. 192) (eds. Walter, H., Brooks, D.E. & Srere, P.A.) 255–280 (Academic Press, 1999).

    Book  Google Scholar 

  9. Moehlenbrock, M.J., Toby, T.K., Waheed, A. & Minteer, S.D. J. Am. Chem. Soc. 132, 6288–6289 (2010).

    Article  CAS  Google Scholar 

  10. Bai, X.-C., McMullan, G. & Scheres, S.H.W. Trends Biochem. Sci. 40, 49–57 (2015).

    Article  CAS  Google Scholar 

Download references

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  1. Danielle Tullman-Ercek is in the Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, California, USA.,

    Danielle Tullman-Ercek

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  1. Danielle Tullman-Ercek
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Correspondence to Danielle Tullman-Ercek.

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The author declares no competing financial interests.

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Tullman-Ercek, D. 'Channeling' Hans Krebs. Nat Chem Biol 11, 180–181 (2015). https://doi.org/10.1038/nchembio.1758

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