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Natural products

Untwisting the antibiotic'ome

Nature Chemical Biology volume 11, pages 177–178 (2015)Cite this article

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Microbial natural products and the specific subset with antibiotic activity, 'the antibiotic'ome', consist of a dizzying array of structures and exert their effects by many known modes of action. In this issue, Cociancich et al. describe a unique natural product that—along with a compound identified in a recent publication by Baumann et al.—defines a new antibacterial chemical scaffold that acts on a rarely hit target, DNA gyrase subunit A.

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Figure 1: New, exotic DNA gyrase inhibitors from the antibiotic'ome.

References

  1. Newman, D.J. & Cragg, G.M. J. Nat. Prod. 70, 461–477 (2007).

    Article  CAS  Google Scholar 

  2. Cociancich, S. et al. Nat. Chem. Biol. 11, 195–197 (2015).

    Article  CAS  Google Scholar 

  3. Birch, R.G. & Patil, S.S. Phytopathology 73, 1368–1374 (1983).

    Article  Google Scholar 

  4. Huang, G.Z., Zhang, L.H. & Birch, R.G. Microbiology 147, 631–642 (2001).

    Article  CAS  Google Scholar 

  5. Piel, J. Nat. Prod. Rep. 27, 996–1047 (2010).

    Article  CAS  Google Scholar 

  6. Vivien, E. et al. Antimicrob. Agents Chemother. 51, 1549–1552 (2007).

    Article  CAS  Google Scholar 

  7. Stachelhaus, T., Mootz, H.D. & Marahiel, M.A. Chem. Biol. 6, 493–505 (1999).

    Article  CAS  Google Scholar 

  8. Kretz, J. et al. Angew. Chem. Int. Edn. Engl. 10.1002/anie.201409584 (12 December 2014).

  9. Baumann, S. et al. Angew. Chem. Int. Edn. Engl. 53, 14605–14609 (2014).

    Article  CAS  Google Scholar 

  10. Tran, J.H. & Jacoby, G.A. Proc. Natl. Acad. Sci. USA 99, 5638–5642 (2002).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Chad W. Johnston and Nathan A. Magarvey are in the Department of Biochemistry and Biomedical Sciences, the Department of Chemistry and Chemical Biology and the M.G. DeGroote Institute of Infectious Disease at McMaster University, Hamilton, Ontario, Canada.,

    Chad W Johnston & Nathan A Magarvey

  2. Nathan A. Magarvey is also a Canada Research Chair in Natural Products & Chemical Biology.,

    Nathan A Magarvey

Authors
  1. Chad W Johnston
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  2. Nathan A Magarvey
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Correspondence to Nathan A Magarvey.

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The authors declare no competing financial interests.

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Johnston, C., Magarvey, N. Untwisting the antibiotic'ome. Nat Chem Biol 11, 177–178 (2015). https://doi.org/10.1038/nchembio.1757

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