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Metals

Setting a trap for copper

In the assembly of metalloenzymes, the matching of metals and proteins must occur with absolute precision. When zinc-starved, Chlamydomonas maintains its balance of metals by sequestering copper in electron-dense traps for metals, thus preventing mishaps in protein metallation.

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Figure 1: Trapping copper under conditions of zinc starvation stress.

References

  1. Cvetkovic, A. et al. Nature 466, 779–782 (2010).

    Article  CAS  Google Scholar 

  2. Waldron, K.J., Rutherford, J.C., Ford, D. & Robinson, N.J. Nature 460, 823–830 (2009).

    Article  CAS  Google Scholar 

  3. Hong-Hermesdorf, A. et al. Nat. Chem. Biol. doi:10.1038/nchembio.1662 (26 October 2014).

    Article  CAS  Google Scholar 

  4. Irving, H. & Williams, R.J.P. J. Chem. Soc. 3192–3210 (1953).

  5. Tottey, S. et al. Nature 455, 1138–1142 (2008).

    Article  CAS  Google Scholar 

  6. Rae, T.D., Schmidt, P.J., Pufhal, R.A., Culotta, V.C. & O'Halloran, T.V. Science 284, 805–808 (1999).

    Article  CAS  Google Scholar 

  7. O'Halloran, T.V. & Culotta, V.C. J. Biol. Chem. 275, 25057–25060 (2000).

    Article  CAS  Google Scholar 

  8. Merchant, S.S. et al. Biochim. Biophys. Acta 1763, 578–594 (2006).

    Article  CAS  Google Scholar 

  9. Malasarn, D. et al. J. Biol. Chem. 288, 10672–10683 (2013).

    Article  CAS  Google Scholar 

  10. Eide, D.J. Metallomics 3, 1124–1129 (2011).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Valeria Culotta.

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Culotta, V. Setting a trap for copper. Nat Chem Biol 10, 986–987 (2014). https://doi.org/10.1038/nchembio.1686

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