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Drug selectivity

Running in the family

Comprehensive selectivity profiling is key for the development of safe drugs. Few current methods are capable of profiling large compound sets against entire target classes. The new EnPlex method expands the existing toolbox, allowing for the surveying of the serine hydrolase enzyme family.

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Figure 1: Comprehensive screening of drug target families by highly multiplexed technologies.

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Correspondence to Gerard Drewes.

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The authors are employees and shareholders of Cellzome GmbH and GlaxoSmithKline.

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Muelbaier, M., Drewes, G. Running in the family. Nat Chem Biol 10, 608–609 (2014). https://doi.org/10.1038/nchembio.1585

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