Comprehensive selectivity profiling is key for the development of safe drugs. Few current methods are capable of profiling large compound sets against entire target classes. The new EnPlex method expands the existing toolbox, allowing for the surveying of the serine hydrolase enzyme family.
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References
Bowes, J. et al. Nat. Rev. Drug Discov. 11, 909–922 (2012).
Bachovchin, D.A. et al. Nat. Chem. Biol. 10.1038/nchembio.1578 (6 July 2014)
Bachovchin, D.A. & Cravatt, B.F. Nat. Rev. Drug Discov. 11, 52–68 (2012).
Liu, Y., Patricelli, M.P. & Cravatt, B.F. Proc. Natl. Acad. Sci. USA 96, 14694–14699 (1999).
Fabian, M.A. et al. Nat. Biotechnol. 23, 329–336 (2005).
Bachovchin, D.A. et al. Proc. Natl. Acad. Sci. USA 107, 20941–20946 (2010).
Cravatt, B.F., Wright, A.T. & Kozarich, J.W. Annu. Rev. Biochem. 77, 383–414 (2008).
Bantscheff, M. et al. Nat. Biotechnol. 25, 1035–1044 (2007).
Bantscheff, M. et al. Nat. Biotechnol. 29, 255–265 (2011).
Patricelli, M.P. et al. Chem. Biol. 18, 699–710 (2011).
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The authors are employees and shareholders of Cellzome GmbH and GlaxoSmithKline.
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Muelbaier, M., Drewes, G. Running in the family. Nat Chem Biol 10, 608–609 (2014). https://doi.org/10.1038/nchembio.1585
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DOI: https://doi.org/10.1038/nchembio.1585