Advances in genome sequencing and structural biology mean that we are now buried under an avalanche of predicted domains and structures of proteins with unknown functions. Two groups have used different methods to unearth the functions of previously cryptic bacterial enzymes, illuminating new reactions and metabolic pathways.
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Wargo, M. Digging up enzyme functions. Nat Chem Biol 10, 4–5 (2014). https://doi.org/10.1038/nchembio.1413
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DOI: https://doi.org/10.1038/nchembio.1413
