Structural biology

Torqueing about pores

Cryo-EM, crystallography, biochemical experiments and computational approaches have been used to study different intermediate states of the Aeromonas hydrophila toxin aerolysin en route to pore formation. These results reveal that an unexpected and marked rotation of the core aerolysin machinery is required to unleash the membrane-spanning regions.

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Figure 1: Figure showing the movement from prepore to pore.

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Correspondence to James C Whisstock.

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Whisstock, J., Dunstone, M. Torqueing about pores. Nat Chem Biol 9, 605–606 (2013). https://doi.org/10.1038/nchembio.1341

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