Pseudomonas aeruginosa uses several intertwined cell-cell communication systems, called quorum sensing (QS) systems, to control gene expression. A QS signal–dependent transcription factor called LasR is at the top of the network. Mutations in lasR inactivate QS, but a new study has revealed an alternate signaling pathway that allows Pseudomonas aeruginosa to bypass LasR and activate a subset of quorum-controlled genes in times of stress.
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Dandekar, A., Greenberg, E. Plan B for quorum sensing. Nat Chem Biol 9, 292–293 (2013). https://doi.org/10.1038/nchembio.1233
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DOI: https://doi.org/10.1038/nchembio.1233
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