Secreted Hedgehog (Hh) proteins are essential in development, and their aberrant activity contributes to certain cancers. Chemically targeting a lipid modification of Hh proteins results in loss of their cellular activity, revealing new strategies for cancer intervention and elucidation of the role of lipids in signal transduction.
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L.L. is an inventor on a pending patent for Wnt pathway inhibitors. C.F. and L.L. are inventors on a pending patent for Hedgehog pathway inhibitors.
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Fan, Cw., Tuladhar, R. & Lum, L. Making a leaner Hedgehog. Nat Chem Biol 9, 217–218 (2013). https://doi.org/10.1038/nchembio.1209
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DOI: https://doi.org/10.1038/nchembio.1209
