Control of protein self-assembly and disassembly, which is central to metabolism and engineering applications, remains challenging. Here, a perspicacious redesign of interfaces in the multisubunit ferritin protein cage provides single, modifiable subunits that assemble with Cu2+ templating and give insights into the cage assembly code.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Douglas, T. & Young, M. Science 312, 873–875 (2006).
Tanaka, S. et al. Science 319, 1083–1086 (2008).
Theil, E.C. Curr. Opin. Chem. Biol. 15, 304–311 (2011).
Huard, D.J.E., Kane, K.M. & Tezcan, F.A. Nat. Chem. Biol. 9, 169–176 (2013).
Kobayashi, M. et al. Chem. Commun. (Camb.) 47, 3475–3477 (2011).
Terashima, M. et al. Biomaterials 32, 1430–1437 (2011).
Tosha, T., Ng, H.L., Bhattasali, O., Alber, T. & Theil, E.C. J. Am. Chem. Soc. 132, 14562–14569 (2010).
Turano, P., Lalli, D., Felli, I.C., Theil, E.C. & Bertini, I. Proc. Natl. Acad. Sci. USA 107, 545–550 (2010).
Bertini, I. et al. J. Am. Chem. Soc. 134, 6169–6176 (2012).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Theil, E., Turano, P. Cage redesign explains assembly. Nat Chem Biol 9, 143–144 (2013). https://doi.org/10.1038/nchembio.1182
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.1182