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Glycobiology

The case of the missing base

Nature Chemical Biology volume 8, pages 952–953 (2012)Cite this article

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Post-translational modification of proteins by N-acetylglucosamine (O-GlcNAc) is carried out by a single glycosyltransferase, OGT. Two independent groups have generated structures of ternary complexes that elegantly illuminate substrate and product binding modes, and thus the overall reaction coordinate, but the respective authors differ in their choice of catalytic base.

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Figure 1: Two proposed mechanisms for O-GlcNAc transfer by OGT.

Change history

  • 13 November 2012

    In the version of this article initially published online, the wrong article was listed as reference 4. The error has been corrected for the PDF and HTML versions of this article.

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Authors and Affiliations

  1. Stephen G. Withers is at the Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada.,

    Stephen G Withers

  2. Gideon J. Davies is at the Department of Chemistry, The University of York, York, UK.,

    Gideon J Davies

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  1. Stephen G Withers
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  2. Gideon J Davies
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Correspondence to Stephen G Withers or Gideon J Davies.

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Withers, S., Davies, G. The case of the missing base. Nat Chem Biol 8, 952–953 (2012). https://doi.org/10.1038/nchembio.1117

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