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Alkaloid synthesis

Back to basics

Taking inspiration from a proposed biosynthetic sequence, a cascade of simple reactions leads to an efficient synthesis of the alkaloid natural product (+)-fastigiatine.

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Figure 1: The total synthesis of (+)-fastigiatine.


  1. Trost, B. M. Science 254, 1471–1477 (1991).

    Article  CAS  Google Scholar 

  2. Wender, P. A., Verma, V. A., Paxton, T. J. & Pillow, T. H. Acc. Chem. Res. 41, 40–49 (2008).

    Article  CAS  Google Scholar 

  3. Young, I. S. & Baran, P. S. Nature Chem. 1, 193–205 (2009).

    Article  CAS  Google Scholar 

  4. Burns, N. Z., Baran, P. S. & Hoffmann, R. W. Angew. Chem. Int. Ed. 48, 2854–2867 (2009).

    Article  CAS  Google Scholar 

  5. Liau, B. B. & Shair, M. D. J. Am. Chem. Soc. 132, 9594–9595 (2010).

    Article  CAS  Google Scholar 

  6. Kobayashi, J. & Morita, H. In The Alkaloids (ed. Cordell, G. A.) 61, 1–57 (Elsevier, 2005).

    Google Scholar 

  7. Danishefsky, S. Acc. Chem. Res. 12, 66–72 (1979).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Steven L. Castle.

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Loertscher, B., Castle, S. Back to basics. Nature Chem 2, 807–808 (2010).

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