The composition of dynamic small-molecule libraries can be biased by the addition of a target compound — such as a protein — that binds selectively to one of the components in the mixture. The chemistry of the library must, however, be compatible with the target and it has now been shown that aniline-catalysed exchange of acylhydrazones fits the bill.
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Miller, B. Catalysing dynamic libraries. Nature Chem 2, 433–434 (2010). https://doi.org/10.1038/nchem.659
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DOI: https://doi.org/10.1038/nchem.659
