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C–H carbonylation

In situ acyl triflates ace it

A simple palladium catalyst has mediated the facile formation of aroyl triflates — an extremely reactive class of electrophiles. These intermediates, generated in situ, enable the Friedel–Crafts acylation of traditionally unreactive arenes, addressing a significant gap in C–H carbonylation methodology.

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Figure 1: Comparison between different strategies to access acyl triflates and synthetic applicability of the reaction developed by Arndtsen and co-workers1.

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Correspondence to Bill Morandi.

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Lee, Y., Morandi, B. In situ acyl triflates ace it. Nature Chem 10, 116–117 (2018). https://doi.org/10.1038/nchem.2934

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