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Chemical biology

Chromatin chemistry goes cellular

Analysing post-translational modifications of histone proteins as they occur within chromatin is challenging due to their large number and chemical diversity. A major step forward has now been achieved by using split intein chemistry to engineer functionalized histones within cells.

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Figure 1: Chemical biology of chromatin.

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Correspondence to Wolfgang Fischle, Dirk Schwarzer or Henning D. Mootz.

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Fischle, W., Schwarzer, D. & Mootz, H. Chromatin chemistry goes cellular. Nature Chem 7, 371–373 (2015). https://doi.org/10.1038/nchem.2249

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