Enhancing the structural diversity of peptide natural products relies on synthetic modifications that are typically not chemo- or regioselective. A nonribosomal peptide synthetase has now been engineered to incorporate a non-natural amino acid containing a reactive bio-orthogonal handle.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Galan, M. C., McCoy, E. & O'Connor, S. E. Chem. Commun. 3249–3251 (2007).
Riva, E. et al. Angew. Chem. Int. Ed. 53, 1–7 (2014).
Sundermann, U. et al. ACS Chem. Biol. 8, 443–450 (2013).
Hughes, A. J., Detelich, J. F. & Keatinge-Clay, A. T. Med. Chem. Commun. 3, 956–959 (2012).
Koryakina, I., McArthur, J. B., Draelos, M. M. & Williams, G. J. Org. Biomol. Chem. 11, 4449–4458 (2013).
Winter, J. M. et al. Org. Lett. 15, 3774–3777 (2013).
Singh, S. et al. Angew. Chem. Int. Ed. 53, 3965–3969 (2014).
Kries, H. et al. Angew. Chem. Int. Ed. 53, 10105–10108 (2014).
Challis, G. L., Ravel, J. & Townsend, C. A. Chem. Biol. 7, 211–224 (2000).
Eppelmann, K., Stachelhaus, T. & Marahiel, M. A. Biochemistry 41, 9718–9726 (2002).
Conti, E., Stachelhaus, T., Marahiel, M. A. & Brick, P. EMBO J. 16, 4174–4183 (1997).
About this article
Cite this article
Winter, J., Tang, Y. Getting a handle on peptides. Nature Chem 6, 1037–1038 (2014). https://doi.org/10.1038/nchem.2117