Intramolecular aliphatic C–H amination reactions are greatly sought-after for the synthesis of N-containing heterocycles, but current methods require the use of highly activated nitrogen sources. Now, aziridination and lactamization have been achieved using fully aliphatic, unactivated, secondary amines.
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Zatolochnaya, O., Gevorgyan, V. The road less travelled to amination. Nature Chem 6, 661–663 (2014). https://doi.org/10.1038/nchem.2018
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DOI: https://doi.org/10.1038/nchem.2018
